In 2016, the State Water Resources Control Board approved a selenium TMDL for North San Francisco Bay. The TMDL established a target concentration of 11.3 μg/g dw in white sturgeon muscle tissue as the basis for evaluating impairment (SFBRWQCB 2015). Following discussions surrounding the North Bay TMDL, the San Francisco Bay Regional Water Quality Control Board asked the RMP Selenium Workgroup to develop a robust monitoring design for North Bay. The purpose of this Sampling and Analysis Plan is to clearly document the sampling design, methods, and responsibilities; and to facilitate coordination among project partners.