This report details plans associated with the 2023 Regional Monitoring Program for Water Quality in the San Francisco Estuary (RMP) water cruise. The RMP water sampling program was redesigned in 2002 to adopt a randomized sampling design at thirty-one stations in place of the twenty-six base program stations sampled previously. In 2007, the number of stations was decreased to twenty-two stations, and it remains as such for 2023. The analytes for 2023 are based on the Status and Trends (S&T) Review process that started in 2020.