SF Bay RMP Webinar: Introduction to Predictive Toxicology
March 10, 2020 - 8:30am to 12:30pm
The Regional Monitoring Program for Water Quality in San Francisco Bay (Bay RMP) combines financial support, direction, and participation by regulatory agencies and the regulated community in a model of collective responsibility. The San Francisco Estuary Institute (SFEI) administers this program. The Bay RMP uses a tiered risk-based framework for prioritizing monitoring of contaminants of emerging concern (CECs).
The RMP is considering using predictive toxicological tools to inform risk-based prioritization for CECs for which there is limited toxicity data, but many staff and stakeholders are not toxicologists and do not know very much about predictive toxicology. This webinar is designed to provide RMP staff and stakeholders with basic knowledge of available predictive toxicology techniques, including their limitations, to inform which tool(s) we could begin to explore as part of our strategy for prioritizing contaminants for study.
In particular, we will cover
- Adverse outcome pathways and how biological understanding drives better ecological risk assessment
- In-vitro methods for predicting in-vivo toxicity
- Translating in vitro and omics results to predicted ecological effects
- How predictive toxicology is being incorporated into environmental regulations, especially in California
- How regional monitoring programs can incorporate predictive toxicology techniques to help prioritize sample sites for further study
- Next steps for planning studies using predictive toxicology in the Bay RMP
- Available computational tools for predicting effects, and their strengths/drawbacks
Programs and Focus Areas:
Bay Regional Monitoring Program