The California State Water Resources Control Board (SWRCB) is developing nutrient water quality objectives for the State’s surface waters, using an approach known as the Nutrient Numeric Endpoint (NNE) framework. The NNE establishes a suite of numeric endpoints based on the ecological response of an aquatic waterbody to nutrient over-enrichment (eutrophication, e.g. algal biomass, dissolved oxygen). In addition to numeric endpoints for response indicators, the NNE framework must include models that link the response indicators to nutrient loads and other management controls. The NNE framework is intended to serve as numeric guidance to translate narrative water quality objectives. The NNE framework is currently under development for estuaries. Because San Francisco Bay represents California’s largest estuary (70% by area of estuarine habitat statewide), it merits development of an estuary-specific NNE framework. The purpose of this document is to review literature and data relevant to the assessment of eutrophication in San Francisco Bay, with the goal of providing information to formulate a work plan to develop NNEs for this estuary. The review had three objectives: 1) Evaluate indicators to assess eutrophication and other adverse effects of anthropogenic nutrient loading in San Francisco Bay, 2) Summarize existing literature in SF Bay using indicators and identify data gaps, and 3) Investigate what data and tools exist to evaluate the trends in nutrient loading to the Bay.