Organophosphate esters (OPEs) and bisphenols are two classes of mobile, endocrine-disrupting chemicals that are ubiquitously detected in environmental matrices due to high global production and use, particularly as plastic and polymer additives. In a 2017 San Francisco Baywide study of 22 OPEs and 16 bisphenols in open-Bay water samples, concentrations were quantified and compared to protective ecotoxicity thresholds, where available, to assess potential risks to wildlife. Fifteen of 22 OPEs were detected. Concentrations of OPEs and bisphenols observed in this study were generally consistent with reported concentrations in other estuarine and marine settings globally. TDCIPP exceeded existing predicted no-effect concentrations (PNECs) at some sites, and six other compounds (TCrP, IDDPP, EHDPP, TPhP, TBOEP, and BPA) were observed at levels approaching individual compound PNECs (not considering mixture effects), indicating potential risks to Bay biota. These results emphasize the need to control releases of these contaminants in order to protect the ecosystem. Periodic monitoring can be used to maintain vigilance in the face of potential regrettable substitutions.